Symbol
Name
ID

Lmx1b
LIM homeobox transcription factor 1 beta
MGI:1100513

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Spina bifida	Abnormal cranial nerve physiology	Tip-toe gait	Seizure	Impaired pain sensation	Impaired temperature sensation	Acroparesthesia
Disease(s) Associated with LMX1B
nail-patella syndrome

Mouse Phenotypes

nervous system phenotype

decreased rhombomere 1 size

abnormal brain development

abnormal midbrain-hindbrain boundary development

absent midbrain-hindbrain boundary

abnormal Raphe nucleus morphology

abnormal tectum morphology

abnormal superior colliculus morphology

decreased superior colliculus size

small tectum

abnormal pretectal region morphology

abnormal cerebral cortex morphology

abnormal cerebellum morphology

absent cerebellum

small cerebellum

abnormal sensory neuron innervation pattern

abnormal neuron morphology

abnormal dopaminergic neuron morphology

decreased motor neuron number

decreased neuronal precursor cell number

increased neuron number

abnormal serotonergic neuron morphology

abnormal optic nerve morphology

abnormal long-term potentiation

abnormal long-term depression

decreased neurotransmitter release

Availability

Mouse Genotype

Lmx1b^Icst/Lmx1b^Icst

Lmx1b^tm1Rjo/Lmx1b^tm1Rjo

Lmx1b^Icst/Lmx1b⁺

Lmx1b^tm1Zfc/Lmx1b^tm1Zfc
Tg(Fev-cre)1Esd/0 (conditional)

Lmx1b^tm1Rjo/Lmx1b^tm1Zfc
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Lmx1b^tm1Rjo/Lmx1b^tm1Zfc
Tg(Lmx1a-cre)1Kjmi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23